Botox is an excellent adjunct for rejuvenation of the lower face. It should be considered in addition to surgery, resurfacing, skin care, and filler materials to improve the appearance of the lower face. Excellent control and familiarity with the toxin is essential before injecting these rewarding although technically more demanding areas of the face. In the perioral area, a few stray units in the wrong muscle or wrong portion of a muscle will guarantee an unhappy patient; this is not an area for the novice injector. When first beginning to inject the lower face, lower doses and more frequent touch-ups are better than larger initial doses and severe complications.