Efficacy of low dose clofarabine in refractory precursor T- acute lymphoblastic leukemia

Yale J Biol Med. 2006 Dec;79(3-4):169-72.

Abstract

Refractory T-lymphoblastic leukemia in adults has a poor prognosis in patients who relapse after allogeneic stem cell transplantation, and relatively few new agents have demonstrated activity. Clofarabine is a novel nucleoside analog that has been associated with significant clinical activity in relapsed pediatric B-ALL. We used low dose clofarabine and induced a remission in a patient who relapsed in the skin and marrow after allogeneic transplant and was refractory to nelarabine and report a near complete response, suggesting significant activity for low intermittent dose clofarabine in patients with relapsed T-cell leukemias.

Publication types

  • Case Reports

MeSH terms

  • Adenine Nucleotides / therapeutic use*
  • Adult
  • Arabinonucleosides / pharmacology
  • Arabinonucleosides / therapeutic use*
  • Bone Marrow Neoplasms / drug therapy
  • Bone Marrow Neoplasms / secondary
  • Clinical Trials as Topic
  • Clofarabine
  • Drug Administration Schedule
  • Drug Resistance, Neoplasm
  • Humans
  • Immunophenotyping
  • Leukemia-Lymphoma, Adult T-Cell / drug therapy*
  • Male
  • Recurrence
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / secondary
  • Stem Cell Transplantation
  • Transplantation, Homologous
  • Treatment Outcome

Substances

  • Adenine Nucleotides
  • Arabinonucleosides
  • nelarabine
  • Clofarabine