CSF IgH gene rearrangement analysis in isolated post-transplant lymphoproliferative disorder of the central nervous system

Joachim M Baehring; Marie-Louise Landry; Dennis Cooper; Pei Hui; Serguei Bannykh

doi:10.1007/s11060-007-9429-9

CSF IgH gene rearrangement analysis in isolated post-transplant lymphoproliferative disorder of the central nervous system

J Neurooncol. 2008 Jan;86(1):57-60. doi: 10.1007/s11060-007-9429-9. Epub 2007 Oct 2.

Authors

Joachim M Baehring¹, Marie-Louise Landry, Dennis Cooper, Pei Hui, Serguei Bannykh

Affiliation

¹ Department of Neurology and Neurosurgery, Yale University School of Medicine, 333 Cedar Street, TMP412, New Haven, CT 06510, USA. Joachim.baehring@yale.edu

PMID: 17909942
DOI: 10.1007/s11060-007-9429-9

Abstract

Isolated post-transplant lymphoproliferative disorder (PTLD) of the central nervous system is rare and its diagnosis can be challenging. A biopsy is usually required in order to distinguish the disease from opportunistic infections. We present a case in whom immunoglobulin heavy chain gene rearrangement analysis of cerebrospinal fluid (CSF) was instrumental in establishing the diagnosis.

Publication types

Case Reports

MeSH terms

Aged
Antigens, CD20 / metabolism
Central Nervous System / pathology*
Female
Gene Rearrangement / physiology*
Humans
Immunoglobulin Heavy Chains / cerebrospinal fluid*
Kidney Transplantation / adverse effects
Lymphoproliferative Disorders / cerebrospinal fluid*
Lymphoproliferative Disorders / etiology
Lymphoproliferative Disorders / immunology*
Lymphoproliferative Disorders / pathology*
Magnetic Resonance Imaging / methods

Substances

Antigens, CD20
Immunoglobulin Heavy Chains