Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis

Antimicrob Agents Chemother. 2007 Dec;51(12):4495-7. doi: 10.1128/AAC.00753-07. Epub 2007 Sep 17.

Abstract

Diethyldithiocarbamate (DETC) and pyrrolidine dithiocarbamate (PDTC) were highly active against tubercle bacilli, with MICs of 8 microg/ml and 0.13 microg/ml, respectively. DETC and PDTC were active against old cultures, enhanced pyrazinamide or pyrazinamide/rifampin activity, and had serum inhibitory titers of 1:2 and 1:4, respectively, in mice given 100 mg/kg orally.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antitubercular Agents / pharmacology
  • Ditiocarb / pharmacology*
  • Female
  • Mice
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / growth & development
  • Pyrazinamide / pharmacology
  • Pyrrolidines / pharmacology*
  • Rifampin / pharmacology
  • Thiocarbamates / pharmacology*

Substances

  • Antitubercular Agents
  • Pyrrolidines
  • Thiocarbamates
  • pyrrolidine dithiocarbamic acid
  • Pyrazinamide
  • Ditiocarb
  • Rifampin