CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response

Nat Struct Mol Biol. 2007 Aug;14(8):710-5. doi: 10.1038/nsmb1277. Epub 2007 Jul 22.

Abstract

The product of the breast cancer-1 gene, BRCA1, plays a crucial part in the DNA damage response through its interactions with many proteins, including BACH1, CtIP and RAP80. Here we identify a coiled-coil domain-containing protein, CCDC98, as a BRCA1-interacting protein. CCDC98 colocalizes with BRCA1 and is required for the formation of BRCA1 foci in response to ionizing radiation. Moreover, like BRCA1, CCDC98 has a role in radiation sensitivity and damage-induced G2/M checkpoint control. Together, these results suggest that CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Motifs
  • BRCA1 Protein / metabolism*
  • Carrier Proteins / chemistry
  • Carrier Proteins / metabolism
  • Carrier Proteins / physiology*
  • Cell Cycle / physiology
  • Cell Line
  • DNA Damage*
  • DNA Repair
  • Humans
  • Protein Interaction Mapping
  • Protein Structure, Tertiary
  • Signal Transduction

Substances

  • ABRAXAS1 protein, human
  • BRCA1 Protein
  • Carrier Proteins