Many methodologies have been employed in training laboratory medicine (clinical pathology) residents. Apprenticeship activities (observing and reproducing the job of an attending clinical pathologist in a direct practice setting) likely remain the most popular for trainees and arguably one of the most effective. The utility and current status of morning report, journal club, resident-led-grand rounds style presentations, faculty didactics, research by residents, placing residents specifically in the role of teachers themselves, hands-on activities in clinical laboratories, and emerging computer-based learning modalities are compared with each other and to similar exercises in other medical disciplines.