piRNAs in the germ line

Science. 2007 Apr 20;316(5823):397. doi: 10.1126/science.1137543.

Abstract

Small noncoding RNAs have emerged as potent regulators of gene expression at both transcriptional and posttranscriptional levels. Recently, a class of small RNAs that interact with Piwi proteins has been discovered in the mammalian germ line and Drosophila. These Piwi-interacting RNAs (piRNAs) represent a distinct small RNA pathway.

Publication types

  • Review

MeSH terms

  • Animals
  • Argonaute Proteins
  • Drosophila
  • Drosophila Proteins / metabolism
  • Epigenesis, Genetic
  • Gene Expression Regulation, Developmental
  • Germ Cells / cytology
  • Germ Cells / metabolism*
  • Mice
  • Peptide Initiation Factors / metabolism
  • Protein Biosynthesis
  • Proteins / metabolism*
  • RNA Stability
  • RNA, Untranslated / genetics
  • RNA, Untranslated / metabolism*
  • RNA-Induced Silencing Complex

Substances

  • AGO3 protein, Drosophila
  • Argonaute Proteins
  • Drosophila Proteins
  • Peptide Initiation Factors
  • Piwil1 protein, mouse
  • Proteins
  • RNA, Untranslated
  • RNA-Induced Silencing Complex
  • aub protein, Drosophila
  • piwi protein, Drosophila