Abstract
The pleiotropic effects of macrophage migration inhibitory factor (MIF) place it in a central position in the immunopathogenesis of many diseases. Here we discuss the current understanding of MIF's role and highlight it as a potential link between inflammatory activation and malignant progression.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Humans
-
Hypoxia / genetics
-
Hypoxia / immunology
-
Immunity, Innate
-
Inflammation / genetics
-
Inflammation / immunology*
-
Macrophage Migration-Inhibitory Factors / antagonists & inhibitors
-
Macrophage Migration-Inhibitory Factors / genetics
-
Macrophage Migration-Inhibitory Factors / physiology*
-
Mice
-
Neoplasms / genetics
-
Neoplasms / immunology*
-
Neovascularization, Pathologic / genetics
-
Neovascularization, Pathologic / immunology
-
Receptors, Immunologic / physiology
-
Sepsis / genetics
-
Sepsis / immunology
-
Tumor Suppressor Protein p53 / physiology
Substances
-
Macrophage Migration-Inhibitory Factors
-
Receptors, Immunologic
-
Tumor Suppressor Protein p53
-
macrophage migration inhibitory factor receptor