Abstract
Dendritic cells induce the activation of CD8 and CD4 T cells by presenting antigenic peptides on MHC class I and class II molecules, respectively. In a recent Science paper, Dudziak et al. (2007) reveal that these tasks are handled by distinct populations of dendritic cells in vivo.
MeSH terms
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Animals
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Antigen Presentation*
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CD11b Antigen / immunology
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CD4-Positive T-Lymphocytes / immunology
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CD8 Antigens / immunology
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CD8-Positive T-Lymphocytes / immunology
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Dendritic Cells / cytology
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Dendritic Cells / immunology*
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Histocompatibility Antigens Class I / immunology
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Histocompatibility Antigens Class II / immunology
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Lymphocyte Activation
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Mice
Substances
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CD11b Antigen
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CD8 Antigens
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CD8 antigen, alpha chain
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Histocompatibility Antigens Class I
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Histocompatibility Antigens Class II