T-cell recognition of myelin basic protein

K W Wucherpfennig; H L Weiner; D A Hafler

doi:10.1016/0167-5699(91)90126-E

T-cell recognition of myelin basic protein

Immunol Today. 1991 Aug;12(8):277-82. doi: 10.1016/0167-5699(91)90126-E.

Authors

K W Wucherpfennig¹, H L Weiner, D A Hafler

Affiliation

¹ Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA.

PMID: 1716903
DOI: 10.1016/0167-5699(91)90126-E

Abstract

Multiple sclerosis is a chronic inflammatory disease of the central nervous system which has been hypothesized to be autoimmune in nature. To test whether this is the case, Kai Wucherpfennig and colleagues have developed a set of criteria that must be met to satisfy the hypothesis. Here, they present these criteria and assess the extent to which studies to date satisfy them.

Publication types

Review

MeSH terms

Autoantigens
Autoimmune Diseases / etiology
Autoimmune Diseases / therapy
Humans
Lymphocyte Activation
Major Histocompatibility Complex
Multiple Sclerosis / etiology
Multiple Sclerosis / therapy
Myelin Basic Protein / immunology*
Receptors, Antigen, T-Cell / genetics
T-Lymphocytes / immunology*

Substances

Autoantigens
Myelin Basic Protein
Receptors, Antigen, T-Cell