Dynamic helix interactions in transmembrane signaling

Erin E Matthews; Manuela Zoonens; Donald M Engelman

doi:10.1016/j.cell.2006.10.016

Dynamic helix interactions in transmembrane signaling

Cell. 2006 Nov 3;127(3):447-50. doi: 10.1016/j.cell.2006.10.016.

Authors

Erin E Matthews¹, Manuela Zoonens, Donald M Engelman

Affiliation

¹ Department of Chemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA.

PMID: 17081964
DOI: 10.1016/j.cell.2006.10.016

Abstract

Studying how protein transmembrane domains transmit signals across membranes is beset by unique challenges. Here, we discuss the circumstances that have led to success and reflect on what has been learned from these examples. Such efforts suggest that some of the most interesting properties of transmembrane helix interactions may be the least amenable to study by current techniques.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cell Membrane / chemistry
Cell Membrane / genetics
Lipid Bilayers / chemistry
Membrane Lipids / metabolism
Membrane Proteins / chemistry*
Membrane Proteins / genetics
Membrane Proteins / metabolism*
Micelles
Models, Molecular
Models, Structural
Mutation
Protein Conformation
Protein Structure, Secondary
Protein Structure, Tertiary
Protein-Tyrosine Kinases / metabolism
Receptors, Cell Surface / genetics
Receptors, Cell Surface / metabolism
Signal Transduction*

Substances

Lipid Bilayers
Membrane Lipids
Membrane Proteins
Micelles
Receptors, Cell Surface
Protein-Tyrosine Kinases