Nicotine withdrawal increases body weight, neuropeptide Y and Agouti-related protein expression in the hypothalamus and decreases uncoupling protein-3 expression in the brown adipose tissue in high-fat fed mice

Neurosci Lett. 2007 Jan 3;411(1):72-6. doi: 10.1016/j.neulet.2006.10.014. Epub 2006 Oct 18.

Abstract

Nicotine is known to decrease body weight in normal rodents and human smokers, whereas nicotine withdrawal or smoking cessation can increase body weight. We have found that mice fed a high fat diet do not show the anorectic effect of chronic nicotine treatment, but do increase their body weight following nicotine withdrawal. Nicotine withdrawal is accompanied by increased expression of the orexigenic peptides neuropeptide Y and Agouti-related protein in the hypothalamus, and decreased expression of the metabolic protein uncoupling protein-3 in brown adipose tissue. These data suggest that diet can influence the ability of nicotine to modulate body weight regulation and demonstrate that chronic nicotine exposure results in adaptive changes in central and peripheral molecules which regulate feeding behavior and energy metabolism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue, Brown / drug effects
  • Adipose Tissue, Brown / metabolism*
  • Agouti Signaling Protein
  • Agouti-Related Protein
  • Analysis of Variance
  • Animals
  • Body Weight / drug effects
  • Body Weight / physiology*
  • Dietary Fats / administration & dosage
  • Hypothalamus / drug effects
  • Hypothalamus / metabolism
  • Hypothalamus / pathology*
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Ion Channels / metabolism*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mitochondrial Proteins / metabolism*
  • Neuropeptide Y / metabolism*
  • Nicotine / administration & dosage
  • Nicotine / adverse effects*
  • Nicotinic Agonists / administration & dosage
  • Nicotinic Agonists / adverse effects*
  • Receptors, Adrenergic, beta / genetics
  • Receptors, Adrenergic, beta / metabolism
  • Substance Withdrawal Syndrome / etiology*
  • Substance Withdrawal Syndrome / metabolism
  • Substance Withdrawal Syndrome / pathology
  • Uncoupling Protein 3

Substances

  • AGRP protein, human
  • Agouti Signaling Protein
  • Agouti-Related Protein
  • Agrp protein, mouse
  • Dietary Fats
  • Intercellular Signaling Peptides and Proteins
  • Ion Channels
  • Mitochondrial Proteins
  • Neuropeptide Y
  • Nicotinic Agonists
  • Receptors, Adrenergic, beta
  • UCP3 protein, human
  • Ucp3 protein, mouse
  • Uncoupling Protein 3
  • Nicotine