The inflammasome: first line of the immune response to cell stress

Cell. 2006 Aug 25;126(4):659-62. doi: 10.1016/j.cell.2006.08.002.

Abstract

The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines. Recent work indicates that the NALP3-inflammasome can be activated by endogenous "danger signals" as well as compounds associated with pathogens (Kanneganti et al., 2006; Mariathasan et al., 2006, Martinon et al., 2006; Sutterwala et al., 2006). Here, we discuss new insights into the regulation of caspase-1 activity in the inflammatory response.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Apoptosis Regulatory Proteins / genetics
  • Apoptosis Regulatory Proteins / metabolism
  • CARD Signaling Adaptor Proteins
  • Calcium Pyrophosphate / metabolism
  • Calcium-Binding Proteins / genetics
  • Calcium-Binding Proteins / metabolism
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Caspase 1 / metabolism*
  • Cytoskeletal Proteins / genetics
  • Cytoskeletal Proteins / metabolism
  • Enzyme Activation
  • Humans
  • Immune System / physiology*
  • Inflammation / metabolism*
  • Interleukins / immunology
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Oxidative Stress*
  • Salmonella Infections / immunology
  • Salmonella typhimurium / immunology
  • Uric Acid / metabolism

Substances

  • Apoptosis Regulatory Proteins
  • CARD Signaling Adaptor Proteins
  • Calcium-Binding Proteins
  • Carrier Proteins
  • Cytoskeletal Proteins
  • Interleukins
  • Ipaf protein, mouse
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human
  • Pycard protein, mouse
  • Uric Acid
  • Adenosine Triphosphate
  • Caspase 1
  • Calcium Pyrophosphate