Heterotrimeric G protein signaling: Getting inside the cell

Michael R Koelle

doi:10.1016/j.cell.2006.06.026

Heterotrimeric G protein signaling: Getting inside the cell

Cell. 2006 Jul 14;126(1):25-7. doi: 10.1016/j.cell.2006.06.026.

Author

Michael R Koelle¹

Affiliation

¹ Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520, USA. michael.koelle@yale.edu

PMID: 16839871
DOI: 10.1016/j.cell.2006.06.026

Abstract

Heterotrimeric G proteins have traditionally been thought to transduce signals at the plasma membrane. In this issue, Slessareva et al. (2006) now show that a G protein alpha subunit acts at the endosome to stimulate a phosphatidylinositol 3-kinase to help yeast respond to mating pheromones.

Publication types

Review
Comment

MeSH terms

Cell Membrane / genetics
Cell Membrane / metabolism
Endosomes / genetics
Endosomes / metabolism*
Heterotrimeric GTP-Binding Proteins / genetics
Heterotrimeric GTP-Binding Proteins / metabolism*
Models, Biological
Phosphatidylinositol 3-Kinases / metabolism*
Protein Binding / physiology
Reproduction, Asexual / physiology
Saccharomyces cerevisiae / genetics*
Sex Attractants / metabolism
Signal Transduction / physiology*

Substances

Sex Attractants
Heterotrimeric GTP-Binding Proteins