Integrating adhesion, protrusion, and contraction during cell migration

Martin A Schwartz; Alan Rick Horwitz

doi:10.1016/j.cell.2006.06.015

Integrating adhesion, protrusion, and contraction during cell migration

Cell. 2006 Jun 30;125(7):1223-5. doi: 10.1016/j.cell.2006.06.015.

Authors

Martin A Schwartz¹, Alan Rick Horwitz

Affiliation

¹ Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. maschwartz@virginia.edu

PMID: 16814706
DOI: 10.1016/j.cell.2006.06.015

Abstract

Cell migration is fastest when the strength of the adhesion between the cell and the substrate is neither too strong nor too weak. In this issue of Cell, reveal how adhesion and cytoskeletal dynamics are integrated to optimize migration speed.

Publication types

Comment

MeSH terms

Actins / physiology
Animals
Biomechanical Phenomena
Cell Adhesion / physiology*
Cell Line
Cell Movement / physiology*
Cytoskeleton / physiology
Fibronectins / physiology
Integrins / physiology
Signal Transduction
Surface Properties

Substances

Actins
Fibronectins
Integrins