Abstract
We report 2 life-threatening cases of Burkholderia cepacia sepsis caused by infusate contamination during compounding. Bacterial isolates from the patients' blood cultures and the infusate were indistinguishable by pulsed-field gel electrophoresis. Proper quality controls at a local and national level are important for ensuring safe delivery of compounded medications to patients in all settings, including those outside health care facilities.
MeSH terms
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Bacteremia / etiology*
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Bacteremia / microbiology
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Burkholderia Infections / etiology*
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Burkholderia cepacia* / chemistry
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Catheterization, Central Venous
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Child
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Child, Preschool
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Disease Notification
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Drug Compounding / adverse effects*
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Drug Contamination*
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Electrophoresis, Gel, Pulsed-Field
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Equipment Contamination
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Factor VIII / administration & dosage*
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Factor VIII / adverse effects
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Heparin / administration & dosage*
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Humans
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Infusions, Intravenous
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Male
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Vancomycin / administration & dosage*
Substances
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Vancomycin
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F8 protein, human
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Factor VIII
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Heparin