[Correlation between the expression of HER-2/neu, nm23 protein and local invasion and lymph node metastasis of human LSCC]

Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Mar;20(6):259-61.
[Article in Chinese]

Abstract

Objective: To explore the relationship between the expressions of HER-2/neu, nm23 protein and local invasion and lymp node metastasis of LSCC.

Method: The expression of HER-2/neu, nm23 protein was detected by immunohistochemical technique in 56 patients with human LSCC.

Result: The positive expression rate of HER-2/neu protein in LSCC was not correlated with histological grade (P > 0.05). There was a significant relationship between the expression of HER-2/neu and the clinical stages, lymph node metastasis (P < 0.05, P < 0.01). The positive expression rate of nm23 protein was significantly higher in the group without lymph node metastasis than those with lymph node metastasis (P < 0.01). The negative correlation was found between the nm23 expression and lymph node metastasis of LSCC. Furthermore, the negative correlation was found between the positive expression of HER-2/neu protein and the positive expression of nm23 protein in the group with lymph node metastasis.

Conclusion: The abnormal expression of HER-2/neu, nm23 protein play an important role in development and lymph node metastasis of LSCC.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor
  • Carcinoma, Squamous Cell / metabolism*
  • Carcinoma, Squamous Cell / pathology
  • Female
  • Humans
  • Laryngeal Neoplasms / metabolism*
  • Laryngeal Neoplasms / pathology*
  • Lymph Nodes / pathology
  • Male
  • Middle Aged
  • NM23 Nucleoside Diphosphate Kinases / metabolism*
  • Neoplasm Metastasis
  • Receptor, ErbB-2 / metabolism*

Substances

  • Biomarkers, Tumor
  • NM23 Nucleoside Diphosphate Kinases
  • ERBB2 protein, human
  • Receptor, ErbB-2
  • NME1 protein, human