Mouse ascites Golgi mucin expression abnormalities in natural cycle endometrial biopsies predict subsequent in vitro fertilization-embryo transfer (IVF-ET) failure in patients with previous IVF-ET failures

Fertil Steril. 2006 Jan;85(1):255-8. doi: 10.1016/j.fertnstert.2005.06.060.

Abstract

We performed a double-blinded retrospective cohort study to determine whether endometrial expression of mouse ascites Golgi mucin in a natural, unmedicated cycle predicts subsequent IVF-ET outcome among women with prior IVF-ET failure and poor pre-embryo quality. We found a statistically significant decrease in clinical pregnancy rate among women with abnormal mouse ascites Golgi expression, a test which was found to have high positive predictive value for failed IVF-ET.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ABO Blood-Group System / immunology
  • ABO Blood-Group System / metabolism*
  • Adult
  • Antibodies
  • Biomarkers
  • Biopsy
  • Cohort Studies
  • Embryo Implantation
  • Embryo Transfer*
  • Endometrium / cytology
  • Endometrium / metabolism*
  • Epitopes / immunology
  • Epitopes / metabolism
  • Female
  • Fertilization in Vitro*
  • Humans
  • Mucins / immunology
  • Mucins / metabolism*
  • Predictive Value of Tests
  • Pregnancy
  • Pregnancy Outcome
  • Retrospective Studies
  • Treatment Failure

Substances

  • ABO Blood-Group System
  • Antibodies
  • Biomarkers
  • Epitopes
  • Mucins