A 55-y-old patient with multiple myeloma presented for restaging after chemotherapy and radiation. The patient had undergone vertebroplasty of multiple thoracic vertebrae because of painful compression fractures. The 18F-FDG PET images showed increased activity at the T8 and T10-T12 vertebral bodies. Comparison of the attenuation-corrected and non-attenuation-corrected images demonstrated that the activity was due to an artifact of attenuation correction. The CT scan correlated the sites of vertebroplasty to the 4 foci of increased uptake of 18F-FDG. The increasing use of vertebroplasty for malignant spinal fractures warrants vigilance for this artifact.