Abstract
Following computational analyses, potential non-nucleoside inhibitors of HIV-1 reverse transcriptase have been pursued through synthesis and assaying for anti-viral activity. The general class Het-NH-Ph-U has been considered, where Het is an aromatic heterocycle and U is an unsaturated, hydrophobic group. Results for compounds with Het=2-thiazoyl and 2-pyrimidinyl are the focus of this report.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amines / chemistry*
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Amines / pharmacology
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Drug Resistance, Multiple, Viral
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HIV Infections / drug therapy
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HIV Infections / virology
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HIV Reverse Transcriptase / antagonists & inhibitors*
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Heterocyclic Compounds / chemistry
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Hydrophobic and Hydrophilic Interactions
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Pyrimidines / chemistry
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Reverse Transcriptase Inhibitors / chemical synthesis*
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Reverse Transcriptase Inhibitors / pharmacology
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Structure-Activity Relationship
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Thiazoles / chemistry
Substances
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Amines
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Heterocyclic Compounds
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Pyrimidines
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Reverse Transcriptase Inhibitors
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Thiazoles
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HIV Reverse Transcriptase