Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation

J Neural Transm (Vienna). 2005 Nov;112(11):1479-85. doi: 10.1007/s00702-005-0391-4.

Abstract

The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Amygdala / enzymology*
  • DNA Mutational Analysis
  • Emotions / physiology*
  • Female
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease / genetics
  • Genetic Testing
  • Genetic Variation / genetics*
  • Genotype
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Mood Disorders / enzymology
  • Mood Disorders / genetics
  • Mood Disorders / physiopathology
  • Mutation / genetics
  • Neuropsychological Tests
  • Photic Stimulation
  • Serotonin / biosynthesis*
  • Tryptophan Hydroxylase / genetics*

Substances

  • Genetic Markers
  • Serotonin
  • TPH2 protein, human
  • Tryptophan Hydroxylase