Objective: To explore the induction and control effect of Fas/FasL system in the occurrence and evolution of nasal polyps tissue.
Method: Nasal polyps samples of 40 cases and 5 healthy adults were examined for the genic expressions of factors Fas and FasL by using the method of reverse transcription polymerase chain reaction (RT-PCR).
Result: The results indicated that the expressions of FasL in nasal polyps was high, and the expressions of Fas was low. The average index of correlative quotient was (0.62+/-0.74), (0.14+/-0.25). The positive percentage in epithelial cells of normal nasal mucosa was significant higher than that of nasal polyps. There was no expressions of FasL in normal nasal mucosa, but in nasal polyps there were different degree expressions, mostly in epithelial cells.
Conclusion: The downwards expression of Fas and the upwards expression of FasL in nasal polyps may inhibit the cellular apoptosis and the enhanced hyperplasia.