Immunosurveillance by gammadelta T cells: focus on the murine system

Chem Immunol Allergy. 2005:86:136-150. doi: 10.1159/000086658.

Abstract

Physiologic immune responses are an integration of the activities of several lymphoid cell types that include qualitatively distinct T cell subsets. The contributions that specific T cell subsets make during infection, inflammation, and carcinogenesis is becoming increasingly clear from a variety of mouse models and, importantly, their backcrossing onto different genetic backgrounds. This review considers what we have learned in the mouse about the crucial roles played by gammadelta T cells. We consider how the cells' associations with specific tissues have revealed that T cell responses are regulated locally as well as systemically, and we discuss the implications of this for understanding and enhancing immune surveillance in the clinical setting.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Mice
  • Models, Immunological
  • Neoplasms, Experimental / immunology
  • Neoplasms, Glandular and Epithelial / immunology
  • Receptors, Antigen, T-Cell, gamma-delta / metabolism*
  • T-Lymphocyte Subsets / immunology*

Substances

  • Receptors, Antigen, T-Cell, gamma-delta