Molecular interactions of the IGF system

Adam Denley; Leah J Cosgrove; Grant W Booker; John C Wallace; Briony E Forbes

doi:10.1016/j.cytogfr.2005.04.004

Molecular interactions of the IGF system

Cytokine Growth Factor Rev. 2005 Aug-Oct;16(4-5):421-39. doi: 10.1016/j.cytogfr.2005.04.004.

Authors

Adam Denley¹, Leah J Cosgrove, Grant W Booker, John C Wallace, Briony E Forbes

Affiliation

¹ School of Molecular and Biomedical Science, The University of Adelaide, SA, Australia.

PMID: 15936977
DOI: 10.1016/j.cytogfr.2005.04.004

Abstract

The insulin-like growth factor (IGF) system is a complex network of two soluble ligands; several cell surface transmembrane receptors and six soluble high-affinity binding-proteins. The IGF system is essential for normal embryonic and postnatal growth, and plays an important role in the function of a healthy immune system, lymphopoiesis, myogenesis and bone growth among other physiological functions. Deregulation of the IGF system leads to stimulation of cancer cell growth and survival. In order to manipulate the IGF system in the treatment of certain disorders, we must understand the protein-protein interactions at a molecular level. The complex molecular interactions of the ligands and receptors of the IGF system underlie all the biological actions mentioned above and will be the focus of this review.

Publication types

Review

MeSH terms

Amino Acid Sequence
Animals
Humans
Insulin-Like Growth Factor Binding Proteins / metabolism*
Insulin-Like Growth Factor I / metabolism*
Insulin-Like Growth Factor II / metabolism*
Models, Biological
Models, Molecular
Molecular Sequence Data
Protein Binding
Receptors, Somatomedin / metabolism*

Substances

Insulin-Like Growth Factor Binding Proteins
Receptors, Somatomedin
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II