Abstract
Several iminosugar derivatives were synthesized, and their effects on the secretion of IL-4 and IFN-gamma from the mouse splenocytes were examined. The effects on membrane expression of other T cell-associated molecules (CD3, CD4, CD8) and B cell-associated molecules (CD19) were also investigated. The experimental data demonstrated that synthetic iminosugars hold potential as immunosuppressive agents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, CD19 / biosynthesis
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B-Lymphocytes / drug effects
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B-Lymphocytes / metabolism
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CD3 Complex / biosynthesis
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CD4 Antigens / biosynthesis
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CD8 Antigens / biosynthesis
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Imines / chemical synthesis*
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Imines / chemistry
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Imines / pharmacology
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Immunosuppressive Agents / chemical synthesis*
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Immunosuppressive Agents / chemistry
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Immunosuppressive Agents / pharmacology
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Interferon-gamma / antagonists & inhibitors
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Interferon-gamma / metabolism
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Interleukin-4 / antagonists & inhibitors
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Interleukin-4 / metabolism
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Mice
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Molecular Mimicry
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Monosaccharides / chemistry*
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Spleen / cytology
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Spleen / drug effects
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Spleen / metabolism
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Structure-Activity Relationship
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T-Lymphocytes / drug effects
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T-Lymphocytes / metabolism
Substances
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Antigens, CD19
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CD3 Complex
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CD4 Antigens
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CD8 Antigens
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Imines
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Immunosuppressive Agents
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Monosaccharides
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Interleukin-4
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Interferon-gamma