Toll-like receptor signaling inhibits hepatitis B virus replication in vivo

J Virol. 2005 Jun;79(11):7269-72. doi: 10.1128/JVI.79.11.7269-7272.2005.

Abstract

Toll-like receptors (TLR) play a key role in innate immunity. To examine the ability of diverse TLRs to modulate hepatitis B virus (HBV) replication, HBV transgenic mice received a single intravenous injection of ligands specific for TLR2, TLR3, TLR4, TLR5, TLR7, and TLR9. All of the ligands except for TLR2 inhibited HBV replication in the liver noncytopathically within 24 h in a alpha/beta interferon-dependent manner. The ability of these TLR ligands to induce antiviral cytokines at the site of HBV replication suggests that TLR activation could represent a powerful and novel therapeutic strategy for the treatment of chronic HBV infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Female
  • Hepatitis B e Antigens / genetics
  • Hepatitis B virus / genetics
  • Hepatitis B virus / immunology*
  • Hepatitis B virus / physiology*
  • Immunity, Innate
  • Interferon-alpha / biosynthesis
  • Interferon-beta / biosynthesis
  • Ligands
  • Liver / immunology
  • Liver / virology
  • Male
  • Membrane Glycoproteins / immunology*
  • Membrane Proteins / deficiency
  • Membrane Proteins / genetics
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Receptor, Interferon alpha-beta
  • Receptors, Cell Surface / immunology*
  • Receptors, Interferon / deficiency
  • Receptors, Interferon / genetics
  • Signal Transduction
  • Toll-Like Receptor 2
  • Toll-Like Receptor 3
  • Toll-Like Receptor 4
  • Toll-Like Receptor 5
  • Toll-Like Receptor 7
  • Toll-Like Receptors
  • Virus Replication / immunology*

Substances

  • Hepatitis B e Antigens
  • Interferon-alpha
  • Ligands
  • Membrane Glycoproteins
  • Membrane Proteins
  • Receptors, Cell Surface
  • Receptors, Interferon
  • Toll-Like Receptor 2
  • Toll-Like Receptor 3
  • Toll-Like Receptor 4
  • Toll-Like Receptor 5
  • Toll-Like Receptor 7
  • Toll-Like Receptors
  • Receptor, Interferon alpha-beta
  • Interferon-beta