Abstract
The SoxE genes, Sox8, Sox9 and Sox10, have been shown to modulate glial specification and differentiation in the peripheral nervous system and spinal cord. However, little is known of their expression during brain development. We have therefore analyzed their expression in developing brain, focused on the cerebellum. In situ hybridization showed a striking degree of temporo-spatial variation in their expression in different glial lineages in both chick and mouse. Sox8 appeared both in oligodendrocytes and astrocytes, Sox9 was more abundant in astrocytes and Sox10 was restricted to later stages of oligodendrocyte development.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Astrocytes / cytology
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Astrocytes / metabolism
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Basic Helix-Loop-Helix Transcription Factors
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Cell Differentiation / physiology*
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Cell Lineage / physiology
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Cerebellum / cytology
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Cerebellum / embryology*
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Cerebellum / metabolism
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Chick Embryo
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DNA-Binding Proteins / genetics*
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Gene Expression Regulation, Developmental / physiology*
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High Mobility Group Proteins / genetics
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Mice
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Neoplasm Proteins / genetics
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Nerve Tissue Proteins / genetics
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Neuroglia / cytology
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Neuroglia / metabolism*
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Oligodendrocyte Transcription Factor 2
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Oligodendroglia / cytology
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Oligodendroglia / metabolism
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RNA, Messenger / metabolism
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SOX9 Transcription Factor
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SOXE Transcription Factors
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Species Specificity
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Stem Cells / cytology
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Stem Cells / metabolism*
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Time Factors
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Transcription Factors / genetics*
Substances
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Basic Helix-Loop-Helix Transcription Factors
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DNA-Binding Proteins
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High Mobility Group Proteins
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Neoplasm Proteins
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Nerve Tissue Proteins
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Olig1 protein, mouse
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Olig2 protein, mouse
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Oligodendrocyte Transcription Factor 2
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RNA, Messenger
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SOX9 Transcription Factor
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SOXE Transcription Factors
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Sox10 protein, mouse
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Sox8 protein, mouse
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Sox9 protein, mouse
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Transcription Factors