Macrophage fusion: are somatic and cancer cells possible partners?

Trends Cell Biol. 2005 Apr;15(4):188-93. doi: 10.1016/j.tcb.2005.02.008.

Abstract

Macrophages are present in all tissues and can fuse with themselves to differentiate into multinucleate osteoclasts or giant cells that play a central role in osteoporosis and chronic inflammatory diseases, respectively. Yet, the mechanism by which they fuse remains uncharacterized. The macrophage fusion receptor (MFR) and its ligand CD47 might mediate homotypic fusion of macrophages and allow for their recognition as 'self' before fusion. Although a novel process and controversial idea, macrophages might exploit a similar mechanism for fusion with somatic cells or tumor cells, with resultant organ repair or metastasis, respectively. Hence, macrophages might be the 'double-edged swords' of tissues.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antigens, CD / metabolism
  • Antigens, Differentiation / metabolism
  • CD47 Antigen
  • Cell Fusion
  • Cell Proliferation
  • Humans
  • Macrophages / cytology*
  • Macrophages / metabolism
  • Membrane Glycoproteins / metabolism
  • Neoplastic Stem Cells / cytology*
  • Neoplastic Stem Cells / metabolism
  • Receptors, Immunologic / metabolism

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • CD47 Antigen
  • CD47 protein, human
  • Membrane Glycoproteins
  • Receptors, Immunologic