Oxygen, oxidative stress, hypoxia, and heart failure

J Clin Invest. 2005 Mar;115(3):500-8. doi: 10.1172/JCI24408.

Abstract

A constant supply of oxygen is indispensable for cardiac viability and function. However, the role of oxygen and oxygen-associated processes in the heart is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death. As oxygen is a major determinant of cardiac gene expression, and a critical participant in the formation of ROS and numerous other cellular processes, consideration of its role in the heart is essential in understanding the pathogenesis of cardiac dysfunction.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Cardiac Output, Low / pathology
  • Cardiac Output, Low / physiopathology*
  • Energy Metabolism
  • Gene Expression Regulation
  • Humans
  • Hypertrophy
  • Hypoxia / metabolism*
  • Ion Channels / metabolism
  • Lipids / toxicity
  • Mitochondria / metabolism
  • Myocardial Ischemia / metabolism
  • Myocardium / cytology
  • Myocardium / metabolism
  • Myocardium / pathology
  • Oxidative Stress*
  • Oxygen / metabolism*
  • Reactive Oxygen Species / metabolism
  • Signal Transduction / physiology

Substances

  • Ion Channels
  • Lipids
  • Reactive Oxygen Species
  • Oxygen
  • Calcium