Abstract
A constant supply of oxygen is indispensable for cardiac viability and function. However, the role of oxygen and oxygen-associated processes in the heart is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death. As oxygen is a major determinant of cardiac gene expression, and a critical participant in the formation of ROS and numerous other cellular processes, consideration of its role in the heart is essential in understanding the pathogenesis of cardiac dysfunction.
MeSH terms
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Animals
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Calcium / metabolism
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Cardiac Output, Low / pathology
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Cardiac Output, Low / physiopathology*
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Energy Metabolism
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Gene Expression Regulation
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Humans
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Hypertrophy
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Hypoxia / metabolism*
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Ion Channels / metabolism
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Lipids / toxicity
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Mitochondria / metabolism
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Myocardial Ischemia / metabolism
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Myocardium / cytology
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Myocardium / metabolism
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Myocardium / pathology
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Oxidative Stress*
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Oxygen / metabolism*
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Reactive Oxygen Species / metabolism
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Signal Transduction / physiology
Substances
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Ion Channels
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Lipids
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Reactive Oxygen Species
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Oxygen
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Calcium