Can blood gene expression predict which patients with multiple sclerosis will respond to interferon?

Naftali Kaminski; Anat Achiron

doi:10.1371/journal.pmed.0020033

Can blood gene expression predict which patients with multiple sclerosis will respond to interferon?

PLoS Med. 2005 Feb;2(2):e33; quiz e51. doi: 10.1371/journal.pmed.0020033. Epub 2005 Feb 22.

Authors

Naftali Kaminski¹, Anat Achiron

Affiliation

¹ Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. kaminskin@upmc.edu

Abstract

Gene expression patterns from peripheral blood cells may be useful as biomarkers for monitoring MS progression and response to therapy, argue Kaminski and Achiron

MeSH terms

Adjuvants, Immunologic / pharmacology
Adjuvants, Immunologic / therapeutic use*
Gene Expression Profiling*
Humans
Interferon-beta / pharmacology
Interferon-beta / therapeutic use*
Leukocytes, Mononuclear
Multiple Sclerosis / drug therapy*
Multiple Sclerosis / genetics*
Phenotype
Polymerase Chain Reaction
Predictive Value of Tests
Prognosis
Treatment Outcome

Substances

Adjuvants, Immunologic
Interferon-beta