Abstract
Whether autoimmune mechanisms play a role in the pathogenesis of inclusion body myositis (IBM) is unknown. Human leukocyte antigen (HLA) analysis in 52 patients, including 17 with autoimmune disorders (AIDs), showed that patients were more likely to have antigens from the autoimmune-prone HLA-B8-DR3 ancestral haplotype than healthy control subjects, irrespective of the presence of AIDs. Patients lacked the apparently protective HLA-DR53 antigen. The results provide further support for an autoimmune basis in IBM.
MeSH terms
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Age of Onset
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Aged
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Aged, 80 and over
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Autoimmune Diseases / epidemiology*
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Autoimmune Diseases / genetics
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Autoimmune Diseases / immunology
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Comorbidity
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Female
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Gene Frequency
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Genes, MHC Class I*
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Genes, MHC Class II*
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Genetic Predisposition to Disease
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HLA Antigens / analysis*
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HLA Antigens / genetics
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HLA Antigens / immunology
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HLA-D Antigens / analysis*
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HLA-D Antigens / genetics
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HLA-D Antigens / immunology
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HLA-DR Antigens / analysis
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HLA-DR Antigens / genetics
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HLA-DR Antigens / immunology
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HLA-DRB4 Chains
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Haplotypes / genetics
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Humans
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Male
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Middle Aged
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Myositis, Inclusion Body / epidemiology*
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Myositis, Inclusion Body / genetics
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Myositis, Inclusion Body / immunology
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Netherlands / epidemiology
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Prevalence
Substances
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HLA Antigens
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HLA-D Antigens
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HLA-DR Antigens
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HLA-DR53
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HLA-DRB4 Chains