Abstract
We describe a 75-year-old man with neutropenia in whom bone marrow aspirate and biopsy demonstrated hemophagocytosis associated with myelodysplasia (MDS). Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which recurred upon rechallenge. We propose that myeloid growth factors may be detrimental in patients with MDS-associated hemophagocytosis.
2004 Wiley-Liss, Inc.
MeSH terms
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Aged
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Blood Cell Count
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Bone Marrow / pathology
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Fatal Outcome
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Granulocyte Colony-Stimulating Factor / adverse effects*
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Granulocyte Colony-Stimulating Factor / therapeutic use
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Granulocyte-Macrophage Colony-Stimulating Factor / adverse effects*
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Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use
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Histiocytosis, Non-Langerhans-Cell / blood
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Histiocytosis, Non-Langerhans-Cell / etiology*
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Histiocytosis, Non-Langerhans-Cell / pathology
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Humans
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Male
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Myelodysplastic Syndromes / blood
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Myelodysplastic Syndromes / complications
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Myelodysplastic Syndromes / drug therapy*
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Myelodysplastic Syndromes / pathology
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Neutropenia / blood
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Neutropenia / complications
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Neutropenia / drug therapy
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Neutropenia / pathology
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Recombinant Proteins
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Splenectomy
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Thrombocytopenia / etiology*
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Thrombocytopenia / therapy
Substances
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Recombinant Proteins
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Granulocyte Colony-Stimulating Factor
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Granulocyte-Macrophage Colony-Stimulating Factor