Hemophagocytosis exacerbated by G-CSF/GM-CSF treatment in a patient with myelodysplasia

Sa Wang; Barbara A Degar; Arthur Zieske; Nelofar Q Shafi; Michal G Rose

doi:10.1002/ajh.20202

Hemophagocytosis exacerbated by G-CSF/GM-CSF treatment in a patient with myelodysplasia

Am J Hematol. 2004 Dec;77(4):391-6. doi: 10.1002/ajh.20202.

Authors

Sa Wang¹, Barbara A Degar, Arthur Zieske, Nelofar Q Shafi, Michal G Rose

Affiliation

¹ Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.

PMID: 15551287
DOI: 10.1002/ajh.20202

Abstract

We describe a 75-year-old man with neutropenia in whom bone marrow aspirate and biopsy demonstrated hemophagocytosis associated with myelodysplasia (MDS). Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which recurred upon rechallenge. We propose that myeloid growth factors may be detrimental in patients with MDS-associated hemophagocytosis.

2004 Wiley-Liss, Inc.

Publication types

Case Reports

MeSH terms

Aged
Blood Cell Count
Bone Marrow / pathology
Fatal Outcome
Granulocyte Colony-Stimulating Factor / adverse effects*
Granulocyte Colony-Stimulating Factor / therapeutic use
Granulocyte-Macrophage Colony-Stimulating Factor / adverse effects*
Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use
Histiocytosis, Non-Langerhans-Cell / blood
Histiocytosis, Non-Langerhans-Cell / etiology*
Histiocytosis, Non-Langerhans-Cell / pathology
Humans
Male
Myelodysplastic Syndromes / blood
Myelodysplastic Syndromes / complications
Myelodysplastic Syndromes / drug therapy*
Myelodysplastic Syndromes / pathology
Neutropenia / blood
Neutropenia / complications
Neutropenia / drug therapy
Neutropenia / pathology
Recombinant Proteins
Splenectomy
Thrombocytopenia / etiology*
Thrombocytopenia / therapy

Substances

Recombinant Proteins
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor