The role of thrombospondin-1 in human disease

J Surg Res. 2004 Nov;122(1):135-42. doi: 10.1016/j.jss.2004.05.015.

Abstract

Thrombospondin-1 (TSP-1) is a large matricellular glycoprotein secreted by many cell types. It is a component of the extracellular matrix during active and subacute processes. Due to TSP-1's ability to interact with a variety of matrix proteins and cell-surface receptors, controversy exists about its conflicting functions. In this review, we will discuss the role of TSP-1 in human disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Disease Progression
  • Disease*
  • Humans
  • Neoplasms / physiopathology
  • Neovascularization, Pathologic / metabolism
  • Neovascularization, Physiologic
  • Platelet Aggregation
  • Thrombospondin 1 / metabolism*
  • Vascular Diseases / physiopathology
  • Wound Healing

Substances

  • Thrombospondin 1