Cell adhesion molecules in synapse formation

J Neurosci. 2004 Oct 20;24(42):9244-9. doi: 10.1523/JNEUROSCI.3339-04.2004.

Abstract

Neuronal transmission relies on signals transmitted through a vast array of excitatory and inhibitory neuronal synaptic connections. How do axons communicate with dendrites to build synapses, and what molecules regulate this interaction? There is a wealth of evidence suggesting that cell adhesion molecules (CAMs) provide much of the information required for synapse formation. This review highlights the molecular mechanisms used by CAMs to regulate presynaptic and postsynaptic differentiation.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / physiology
  • Cell Adhesion Molecules / physiology*
  • Dendrites / physiology
  • Humans
  • Synapses / physiology*

Substances

  • Cell Adhesion Molecules