Interferon-gamma deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice

Tian Wang; Mustafa Akkoyunlu; Rila Banerjee; Erol Fikrig

doi:10.1016/j.femsim.2004.06.001

Interferon-gamma deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice

FEMS Immunol Med Microbiol. 2004 Nov 1;42(3):299-305. doi: 10.1016/j.femsim.2004.06.001.

Authors

Tian Wang¹, Mustafa Akkoyunlu, Rila Banerjee, Erol Fikrig

Affiliation

¹ Section of Rheumatology, Department of Internal Medicine, Yale University of School of Medicine, 300 Cedar Street, New Haven, CT, USA.

PMID: 15477043
DOI: 10.1016/j.femsim.2004.06.001

Abstract

Immunocompetent mice 129Sv (129) and C57BL/6 (B6) mice are similarly susceptible to Anaplasma phagocytophilum. We now show that 129 mice lacking interferon-gamma (IFN-gamma) develop more severe infection with A. phagocytophilum than IFN-gamma deficient B6 mice. These data demonstrate that there is an inherent increased susceptibility of 129 mice, compared with B6 mice, to A. phagocytophilum that can only be discerned in the absence of IFN-gamma.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Anaplasma phagocytophilum*
Animals
Chemokine CXCL2
Chemokines / analysis
Chemokines, CXC / analysis
Disease Susceptibility
Ehrlichiosis / etiology*
Ehrlichiosis / immunology
Ehrlichiosis / microbiology
Female
Gene Deletion
Interferon-gamma / genetics*
Interferon-gamma / immunology
Interleukin-12 / analysis
Mice
Mice, Inbred C57BL
Respiratory Burst

Substances

Chemokine CXCL2
Chemokines
Chemokines, CXC
Cxcl2 protein, mouse
Interleukin-12
Interferon-gamma