New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2

Immunol Rev. 2004 Aug:200:261-71. doi: 10.1111/j.0105-2896.2004.00167.x.

Abstract

The lymphoid-specific factors, recombination-activating gene 1 (RAG1) and RAG2, initiate V(D)J recombination by introducing DNA double-stand breaks at specific sites in the genome. In addition to this critical endonuclease activity, the RAG proteins catalyze other chemical reactions that can affect the outcome of V(D)J recombination, one of which is transposition. While the transposition activity of the RAG proteins is thought to have been critical for the evolution of modern antigen-receptor loci, it has also been proposed to contribute to chromosomal translocations and lymphoid malignancy. A major challenge has been to determine how the transposition activity of the RAG proteins is regulated in vivo. Although a variety of mechanisms have been suggested by recent studies, a clear resolution of this issue remains elusive.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / physiology*
  • Gene Rearrangement, B-Lymphocyte*
  • Gene Rearrangement, T-Lymphocyte*
  • Homeodomain Proteins / physiology*
  • Mice
  • Recombination, Genetic
  • Translocation, Genetic
  • Transposases / immunology
  • Transposases / physiology*
  • VDJ Recombinases / immunology
  • VDJ Recombinases / metabolism

Substances

  • DNA-Binding Proteins
  • Homeodomain Proteins
  • Rag2 protein, mouse
  • V(D)J recombination activating protein 2
  • RAG-1 protein
  • Transposases
  • VDJ Recombinases