Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses

Microbes Infect. 2004 Jul;6(8):759-66. doi: 10.1016/j.micinf.2004.03.007.

Abstract

Co-signaling molecules in the B7-CD28 family have been intensively studied over the past decade and have brought much excitement to the field of immune regulation. The discovery of new functions for the classical pathways CD80/CD86/CD28/CTLA-4 and the identification of novel pathways of the family, including B7-H1/B7-DC/PD-1, B7-H2/ICOS, B7-H3, B7-H4 and BTLA, are greatly broadening our understanding of the control of T cell-mediated immune responses and tolerance.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, CD
  • Antigens, Differentiation / physiology
  • Antigens, Differentiation, T-Lymphocyte / physiology
  • Antigens, Surface / physiology
  • Apoptosis Regulatory Proteins
  • B7-1 Antigen / physiology*
  • CD28 Antigens / immunology*
  • CTLA-4 Antigen
  • Down-Regulation
  • Humans
  • Inducible T-Cell Co-Stimulator Ligand
  • Inducible T-Cell Co-Stimulator Protein
  • Ligands
  • Programmed Cell Death 1 Receptor
  • Proteins / immunology*
  • Proteins / physiology*
  • Receptors, Immunologic / physiology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism*
  • Up-Regulation

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface
  • Apoptosis Regulatory Proteins
  • B7-1 Antigen
  • BTLA protein, human
  • CD28 Antigens
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • ICOS protein, human
  • ICOSLG protein, human
  • Inducible T-Cell Co-Stimulator Ligand
  • Inducible T-Cell Co-Stimulator Protein
  • Ligands
  • PDCD1 protein, human
  • Programmed Cell Death 1 Receptor
  • Proteins
  • Receptors, Immunologic