Putting the squeeze on mechanotransduction

Brian P Helmke; Martin A Schwartz

doi:10.1016/j.devcel.2004.05.013

Putting the squeeze on mechanotransduction

Dev Cell. 2004 Jun;6(6):745-6. doi: 10.1016/j.devcel.2004.05.013.

Authors

Brian P Helmke¹, Martin A Schwartz

Affiliation

¹ Department of Biomedical Engineering, University of Virginia, Charlottesville, VA22908, USA.

PMID: 15177022
DOI: 10.1016/j.devcel.2004.05.013

Abstract

Both mechanical and chemical stimuli guide tissue function. In a recent paper, Tschumperlin et al. proposed that pressure acting on airway epithelium elicits mechanotransduction not by directly altering biochemical signaling but by regulating extracellular fluid volume to modulate ligand-receptor interactions.

Publication types

Review

MeSH terms

Air Pressure
Animals
Autocrine Communication / physiology
Extracellular Fluid / physiology
Humans
Ligands
Mechanotransduction, Cellular / physiology*
Models, Biological
Receptors, Cell Surface / physiology
Respiratory Mucosa / cytology
Respiratory Mucosa / physiology*

Substances

Ligands
Receptors, Cell Surface