Possible epistatic role of ADH7 in the protection against alcoholism

Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):19-22. doi: 10.1002/ajmg.b.20136.

Abstract

In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His. Here we present evidence for an additional effect from outside the Class I ADH genes, presumably from functional variation at the ADH7 gene. The protective effect is restricted to one of two haplotypes identical at ADH1B but differing at an intronic SNP at ADH7 suggesting epistasis or strong linkage disequilibrium (LD).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alcohol Dehydrogenase / genetics*
  • Alcoholism / genetics
  • Alcoholism / prevention & control*
  • Epistasis, Genetic*
  • Female
  • Haplotypes / genetics*
  • Humans
  • Introns / genetics
  • Linkage Disequilibrium
  • Male
  • Polymorphism, Single Nucleotide / genetics

Substances

  • Alcohol Dehydrogenase