Histologic features of melanocytic nevi seen in association with mycosis fungoides

J Cutan Pathol. 2003 Nov;30(10):606-10. doi: 10.1034/j.1600-0560.2003.00127.x.

Abstract

Background: Many different tumors have been reported to occur simultaneously as collision lesions. To date, no such events have been reported between mycosis fungoides (MFs) and melanocytic neoplasms.

Methods: Two cases are presented in which patches of MF were superimposed on melanocytic nevi. In addition, 967 biopsies of MF from 411 patients were identified in an 8-year retrospective database search. Patient pathology history summaries were reviewed to identify inflamed nevi, atypical nevi, and melanoma submitted for histologic evaluation from this population.

Results: The occurrence of MF in a congenital nevus was associated with a halo phenomenon restricted to the affected region of the nevus in one patient. In the other patient, nests of two morphologies (lymphocytic and melanocytic) in the same biopsy presented a potentially confusing histologic picture. No other cases of MF superimposed on a nevus were identified in 967 biopsies from 411 patients with a histological diagnosis of MF seen over the past 8 years. In this population, 57 biopsies of melanocytic lesions were identified from 28 patients, including three atypical nevi and three melanomas.

Conclusions: The presence of MF superimposed on a nevus is rare and may lead to confounding histologic features or the development of a halo nevus phenomenon.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Humans
  • Male
  • Mycosis Fungoides / complications*
  • Nevus, Pigmented / complications*
  • Nevus, Pigmented / congenital
  • Nevus, Pigmented / pathology*
  • Skin Neoplasms / complications*
  • Skin Neoplasms / congenital
  • Skin Neoplasms / pathology*