Abstract
Novak et al. [Brain Res. Mol. Brain Res. 107 (2002) 183] reported that a CAA insertion in the 3'-untranslated region of the Nogo gene was associated with schizophrenia. We examined the frequency of this CAA insertion in 57 European American subjects with schizophrenia and 243 controls, and in a smaller group of African American subjects (N=72; 20 with schizophrenia). We found a similar frequency of the CAA insertion for patients and controls in both populations, but a large difference in CAA insertion frequency between the two racial groups.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Black or African American
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Chi-Square Distribution
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DNA Transposable Elements / genetics*
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Gene Frequency
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Genotype
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Humans
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Linkage Disequilibrium
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Molecular Sequence Data
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Mutagenesis, Insertional*
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Myelin Proteins / genetics*
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Myelin Proteins / metabolism
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Nogo Proteins
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Schizophrenia / epidemiology
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Schizophrenia / genetics*
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Untranslated Regions*
Substances
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DNA Transposable Elements
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Myelin Proteins
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Nogo Proteins
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RTN4 protein, human
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Untranslated Regions