Nogo 3'-untranslated region CAA insertion: failure to replicate association with schizophrenia and demonstration of marked population difference in frequency of the insertion

Brain Res Mol Brain Res. 2004 Jan 5;120(2):197-200. doi: 10.1016/j.molbrainres.2003.11.001.

Abstract

Novak et al. [Brain Res. Mol. Brain Res. 107 (2002) 183] reported that a CAA insertion in the 3'-untranslated region of the Nogo gene was associated with schizophrenia. We examined the frequency of this CAA insertion in 57 European American subjects with schizophrenia and 243 controls, and in a smaller group of African American subjects (N=72; 20 with schizophrenia). We found a similar frequency of the CAA insertion for patients and controls in both populations, but a large difference in CAA insertion frequency between the two racial groups.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Black or African American
  • Chi-Square Distribution
  • DNA Transposable Elements / genetics*
  • Gene Frequency
  • Genotype
  • Humans
  • Linkage Disequilibrium
  • Molecular Sequence Data
  • Mutagenesis, Insertional*
  • Myelin Proteins / genetics*
  • Myelin Proteins / metabolism
  • Nogo Proteins
  • Schizophrenia / epidemiology
  • Schizophrenia / genetics*
  • Untranslated Regions*

Substances

  • DNA Transposable Elements
  • Myelin Proteins
  • Nogo Proteins
  • RTN4 protein, human
  • Untranslated Regions