During 2002, 49 states and Puerto Rico reported 7,967 cases of rabies in nonhuman animals and 3 cases in human beings to the Centers for Disease Control and Prevention, an increase of 7.2% from the 7,436 cases in non-human animals and 1 case in a human being reported in 2001. More than 92% (7,375 cases) were in wild animals, whereas 7.4% (592) were in domestic species (compared with 93.3% in wild animals and 6.7% in domestic species in 2001). Compared with cases reported in 2001, the numbers of cases reported in 2002 increased among all major reporting groups with the exception of swine and rodents and lagomorphs. The relative contributions of the major groups of animals were as follows: raccoons (36.3%; 2,891 cases), skunks (30.5%; 2,433), bats (17.2%; 1,373), foxes (6.4%; 508), cats (3.8%; 299), dogs (1.2%; 99), and cattle (1.5%; 116). Thirteen of the 19 states in which the raccoon-associated variant of the rabies virus has been enzootic reported increases in the numbers of rabid raccoons during 2002. Among those states that have engaged in wildlife rabies control programs, Ohio reported 1 case of raccoon rabies associated with the epizootic of rabies in raccoons and 1 case in an equid that was infected with a bat variant of the rabies virus, compared with 2 cases reported in terrestrial animals during 2001. Texas reported no cases of rabies associated with the dog/coyote variant of the rabies virus (compared with 1 case in 2001) and 65 cases associated with the gray fox variant of the virus (an increase of 225% from 20 cases reported in 2001). In Massachusetts and Rhode Island, states with enzootic raccoon rabies, reports of rabid skunks again exceeded those of rabid raccoons (the sixth consecutive year, although in Rhode Island, this difference decreased to only 7 more skunks than raccoons [38/31]). Tennessee reported a single case of raccoon rabies in a pet raccoon from the central part of the state; the captive animal had been transported toTennessee from northern Georgia. Nationally, the number of rabies cases in skunks during 2002 increased by 6.6% over those reported in 2001. Texas reported the greatest number (740) of rabid skunks and the greatest overall state total of rabies cases (1,049) during 2002. The 1,373 cases of rabies reported in bats during 2002 surpassed the previous year's record (1,281 cases) as the largest number of reported cases ever recorded for this group of mammals. Cases of rabies reported in cats (299), cattle (116), and dogs (99) increased by 10.7%, 41.5%, and 11.24%, respectively, from 2001 to 2002. Rabies among sheep and goats increased 400% from 3 cases in 2001 to 15 in 2002, and cases among horses and mules increased 13.7% (51 cases in 2001 to 58 in 2002). Reported cases of rabies in mongooses in Puerto Rico decreased 4.3% from the previous year (70 cases in 2001 to 67 cases in 2002), while cases of rabies in dogs increased 77% (13 to 14). California, Tennessee, and Iowa each reported a case of rabies in a human being during 2002. All cases of rabies in humans were the result of infection with bat variants of the rabies virus.