Abstract
Potent and selective small-molecule mediated inhibition of the cell's replication machinery remains a principal aim in the development of novel therapeutics and biological probes. Recent efforts have identified small molecules capable of arresting the cell cycle via specific interaction with a variety of intracellular protein targets. Advances in combinatorial and diversity oriented synthetic methods, coupled with a continued effort to identify sources of bioactive natural products, promise to contribute to the growing library of small-molecule inhibitors of the cell cycle.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adenosine Triphosphatases / antagonists & inhibitors
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Adenosine Triphosphatases / metabolism
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Animals
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Cell Cycle / drug effects*
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Cell Cycle / physiology*
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Cell Cycle Proteins / antagonists & inhibitors*
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Cell Cycle Proteins / metabolism
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Drug Design
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Enzyme Inhibitors / pharmacology*
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Enzyme Inhibitors / therapeutic use
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Humans
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Molecular Structure
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Protein Kinase Inhibitors
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Protein Kinases / metabolism
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Protein Synthesis Inhibitors / pharmacology
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Protein Synthesis Inhibitors / therapeutic use
Substances
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Cell Cycle Proteins
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Enzyme Inhibitors
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Protein Kinase Inhibitors
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Protein Synthesis Inhibitors
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Protein Kinases
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Adenosine Triphosphatases