Small-molecule inhibitors of the cell cycle: an overview

Prog Cell Cycle Res. 2003:5:125-33.

Abstract

Potent and selective small-molecule mediated inhibition of the cell's replication machinery remains a principal aim in the development of novel therapeutics and biological probes. Recent efforts have identified small molecules capable of arresting the cell cycle via specific interaction with a variety of intracellular protein targets. Advances in combinatorial and diversity oriented synthetic methods, coupled with a continued effort to identify sources of bioactive natural products, promise to contribute to the growing library of small-molecule inhibitors of the cell cycle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenosine Triphosphatases / antagonists & inhibitors
  • Adenosine Triphosphatases / metabolism
  • Animals
  • Cell Cycle / drug effects*
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / antagonists & inhibitors*
  • Cell Cycle Proteins / metabolism
  • Drug Design
  • Enzyme Inhibitors / pharmacology*
  • Enzyme Inhibitors / therapeutic use
  • Humans
  • Molecular Structure
  • Protein Kinase Inhibitors
  • Protein Kinases / metabolism
  • Protein Synthesis Inhibitors / pharmacology
  • Protein Synthesis Inhibitors / therapeutic use

Substances

  • Cell Cycle Proteins
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors
  • Protein Synthesis Inhibitors
  • Protein Kinases
  • Adenosine Triphosphatases