Abstract
The maintenance of vascular function is of paramount importance to an organism's existence. PECAM-1 (CD31), first thought of as a marker for endothelia, has been shown to be an important scaffolding molecule involved in several signaling pathways. Recent studies have demonstrated an even wider range of functions for this versatile molecule including participation in maintenance of adherens junction integrity and permeability, organization of the intermediate filament cytoskeleton, regulation of catenin localization and transcriptional activities, participation in STAT isoform signaling, control of apoptotic events, and modulation of cardiac cushion development.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adherens Junctions / metabolism*
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Animals
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Apoptosis / physiology
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Capillary Permeability / physiology*
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Cell Adhesion Molecules / metabolism
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Cytoskeletal Proteins / metabolism*
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DNA-Binding Proteins / metabolism
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Humans
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Intermediate Filaments / metabolism
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Milk Proteins*
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Models, Molecular
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Phosphorylation
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Platelet Endothelial Cell Adhesion Molecule-1 / metabolism*
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Protein Structure, Tertiary
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STAT5 Transcription Factor
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Signal Transduction / physiology*
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Trans-Activators / metabolism*
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Vascular Endothelial Growth Factor A / metabolism
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alpha Catenin
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beta Catenin
Substances
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CTNNA1 protein, human
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CTNNB1 protein, human
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Cell Adhesion Molecules
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Cytoskeletal Proteins
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DNA-Binding Proteins
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Milk Proteins
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Platelet Endothelial Cell Adhesion Molecule-1
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STAT5 Transcription Factor
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Trans-Activators
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Vascular Endothelial Growth Factor A
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alpha Catenin
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beta Catenin