Treatment of erythrodermic cutaneous T-cell lymphoma with extracorporeal photochemotherapy

J Am Acad Dermatol. 1992 Sep;27(3):427-33. doi: 10.1016/0190-9622(92)70212-x.

Abstract

Background: This original cohort of patients with erythrodermic cutaneous T-cell lymphoma (CTCL) was reported to have clinical improvement with photopheresis during the 12 months of the original study. No long-term follow-up data have been available to examine the impact of this therapy on the disease.

Objective: Our purpose was to provide long-term follow-up on the original 29 erythrodermic CTCL patients treated with photopheresis and to compare these results with historical controls.

Methods: Files of patients from the original photopheresis study centers were reviewed and their current status was documented.

Results: The median survival of the treated patients was 60.33 months from the date of diagnosis and 47.9 months from the date of the start of photopheresis therapy. A complete remission has been maintained in four of the six patients who achieved complete responses in the original study. The best responses were seen in patients with a lower CD4/CD8 ratio in the peripheral blood at the start of therapy.

Conclusion: Photopheresis can influence the natural history of erythrodermic CTCL by inducing remissions and prolonging survival with minimal toxicity.

MeSH terms

  • CD4-CD8 Ratio
  • Dermatitis, Exfoliative / drug therapy*
  • Dermatitis, Exfoliative / immunology
  • Dermatitis, Exfoliative / mortality
  • Dermatitis, Exfoliative / pathology
  • Follow-Up Studies
  • Humans
  • Lymphoma, T-Cell, Cutaneous / drug therapy*
  • Lymphoma, T-Cell, Cutaneous / immunology
  • Lymphoma, T-Cell, Cutaneous / mortality
  • Lymphoma, T-Cell, Cutaneous / pathology
  • Methoxsalen / therapeutic use
  • Photochemotherapy*
  • Skin / pathology
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / immunology
  • Skin Neoplasms / mortality
  • Skin Neoplasms / pathology
  • Survival Rate

Substances

  • Methoxsalen