The H2-receptor antagonist era in duodenal ulcer disease

Yale J Biol Med. 1992 Nov-Dec;65(6):639-48;discussion 689-92.

Abstract

This paper reviews the remarkable impact of H2-receptor antagonists on duodenal ulcer management. The development and the scientific rationale of these agents are presented, and efficacy and safety aspects in the short- and long-term treatment of duodenal ulcer disease discussed. Attention is focused on the possible role of "acid rebound" in ulcer relapse following the withdrawal of therapy and on the clinical relevance of prolonged suppression of acid secretion in patients on long-term therapy.

Publication types

  • Review

MeSH terms

  • Duodenal Ulcer / drug therapy*
  • Duodenal Ulcer / etiology
  • Duodenal Ulcer / physiopathology
  • Histamine H2 Antagonists / therapeutic use*
  • Humans

Substances

  • Histamine H2 Antagonists