Nitric oxide-releasing mesalamine: potential utility for treatment of inflammatory bowel disease

Dig Liver Dis. 2003 May:35 Suppl 2:S35-40. doi: 10.1016/s1590-8658(03)00050-1.

Abstract

Nitric oxide can accelerate ulcer healing and exert anti-inflammatory effects. Addition of a nitric oxide-releasing moiety to mesalamine significantly boosts its anti-inflammatory activity. NO-releasing mesalamine suppresses inflammatory cytokine production and reduces leukocyte infiltration.

Publication types

  • Review

MeSH terms

  • Aminosalicylic Acids / pharmacology
  • Aminosalicylic Acids / therapeutic use*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Apoptosis / drug effects
  • Colitis / drug therapy*
  • Cytokines / biosynthesis
  • Disease Models, Animal
  • Humans
  • Leukocytes / drug effects
  • Mesalamine / pharmacology
  • Mesalamine / therapeutic use*
  • Naproxen / analogs & derivatives*
  • Naproxen / pharmacology
  • Naproxen / therapeutic use*
  • Nitric Oxide / pharmacology
  • Nitric Oxide / therapeutic use*
  • Rats

Substances

  • Aminosalicylic Acids
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cytokines
  • NO-mesalamine
  • naproxen-n-butyl nitrate
  • Nitric Oxide
  • Mesalamine
  • Naproxen