Abstract
Nitric oxide can accelerate ulcer healing and exert anti-inflammatory effects. Addition of a nitric oxide-releasing moiety to mesalamine significantly boosts its anti-inflammatory activity. NO-releasing mesalamine suppresses inflammatory cytokine production and reduces leukocyte infiltration.
MeSH terms
-
Aminosalicylic Acids / pharmacology
-
Aminosalicylic Acids / therapeutic use*
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
-
Apoptosis / drug effects
-
Colitis / drug therapy*
-
Cytokines / biosynthesis
-
Disease Models, Animal
-
Humans
-
Leukocytes / drug effects
-
Mesalamine / pharmacology
-
Mesalamine / therapeutic use*
-
Naproxen / analogs & derivatives*
-
Naproxen / pharmacology
-
Naproxen / therapeutic use*
-
Nitric Oxide / pharmacology
-
Nitric Oxide / therapeutic use*
-
Rats
Substances
-
Aminosalicylic Acids
-
Anti-Inflammatory Agents, Non-Steroidal
-
Cytokines
-
NO-mesalamine
-
naproxen-n-butyl nitrate
-
Nitric Oxide
-
Mesalamine
-
Naproxen