Abstract
Parkinson's disease is characterized by dopamine cell loss of the substantia nigra. Parkinson's disease and the neurotoxin 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine may destroy dopamine neurons through oxidative stress. Coenzyme Q is a cofactor of mitochondrial uncoupling proteins that enhances state-4 respiration and eliminate superoxides. Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Count
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Cell Respiration / drug effects
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Chlorocebus aethiops
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Disease Models, Animal
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Dopamine / physiology*
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Gene Expression / drug effects
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Ion Channels
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Male
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Membrane Transport Proteins*
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Mitochondria / metabolism
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Mitochondrial Proteins*
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Parkinsonian Disorders / drug therapy*
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Parkinsonian Disorders / metabolism
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Parkinsonian Disorders / pathology*
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Proteins / genetics
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RNA, Messenger / analysis
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Substantia Nigra / drug effects
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Substantia Nigra / metabolism
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Substantia Nigra / pathology*
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Ubiquinone / pharmacology*
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Uncoupling Agents / pharmacology
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Uncoupling Protein 2
Substances
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Ion Channels
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Membrane Transport Proteins
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Mitochondrial Proteins
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Proteins
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RNA, Messenger
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Uncoupling Agents
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Uncoupling Protein 2
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Ubiquinone
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Dopamine