Electrostatic fasteners hold the T cell receptor-CD3 complex together

Donald M Engelman

doi:10.1016/s1097-2765(03)00016-9

Electrostatic fasteners hold the T cell receptor-CD3 complex together

Mol Cell. 2003 Jan;11(1):5-6. doi: 10.1016/s1097-2765(03)00016-9.

Author

Donald M Engelman¹

Affiliation

¹ Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.

PMID: 12535514
DOI: 10.1016/s1097-2765(03)00016-9

Abstract

Assembly of the T cell receptor includes the formation of trimers stabilized by electrostatic interactions inside the membrane (Call et al., 2003). Such interactions can strongly stabilize subunit associations while permitting conformation changes during signaling.

MeSH terms

CD3 Complex / chemistry*
CD3 Complex / immunology
Macromolecular Substances
Models, Molecular
Protein Conformation
Receptor-CD3 Complex, Antigen, T-Cell / chemistry*
Receptor-CD3 Complex, Antigen, T-Cell / metabolism
Receptors, Antigen, T-Cell / chemistry*
Receptors, Antigen, T-Cell / immunology
Signal Transduction*
Static Electricity*

Substances

CD3 Complex
Macromolecular Substances
Receptor-CD3 Complex, Antigen, T-Cell
Receptors, Antigen, T-Cell