Abstract
A key question in developmental neurobiology is how the diversity of cell types that make up the mature nervous system are generated from a common set of progenitor cells. Drosophila genes governing temporal cell fate determination and asymmetric cell divisions involving numb may represent evolutionarily conserved mechanisms for regulating cell fate diversification in the developing nervous system.
MeSH terms
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Animals
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Cell Differentiation / physiology*
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Cell Division / physiology*
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Cell Lineage / physiology*
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Drosophila Proteins
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Drosophila melanogaster / cytology
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Drosophila melanogaster / embryology
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Drosophila melanogaster / physiology
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Humans
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Intracellular Signaling Peptides and Proteins
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Juvenile Hormones / genetics
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Juvenile Hormones / metabolism
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism
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Nervous System / cytology
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Nervous System / embryology*
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Neurons / cytology*
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Neurons / physiology
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Stem Cells / cytology*
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Stem Cells / physiology
Substances
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Drosophila Proteins
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Intracellular Signaling Peptides and Proteins
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Juvenile Hormones
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Nerve Tissue Proteins
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Numbl protein, mouse
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numb protein, Drosophila